NCAT PHYSICS COLLOQUIUM SIRIES
Contact: Dr. Abebe Kebede
336-285 2113 or email firstname.lastname@example.org
Hall, Room 310
Time- 4:00 PM
Title: Physical-chemical factors controlling nanoparticle exposure, transformation and reactivity
The properties of nanomaterials are transformed significantly due to interactions with environmental and physiological matrices. This presentation explores the role of nanomaterial-macromolecule interactions as they affect aggregation, deposition and reactivity using fullerenes as an example. The chemistry of reactive oxygen species (ROS) generation is presented and the relationship between the morphology of nanoparticle aggregates and their reactivity is explored. Alternations to nanoparticle ROS production as the result of matrix effects, in particular those representing commonly used growth media, are discussed. Changes in the affinity of fullerenes for a references solid phase are presented as function of the nature of adsorbing macromolecules, and the significance of these results for nanoparticle transport are highlighted. Finally, the importance of accounting for nanoparticle transformations in bioavailability and toxicity studies is discussed.